BrainCare: Scientific research and development of innovative evidence based non-invasive brain diagnostic and monitoring solutions for neurological and TBI patients

BrainCare: Scientific research and development of innovative evidence based non-invasive brain diagnostic and monitoring solutions for neurological and TBI patients. This joint research project runs under Lithuania-Swiss programme "Research and Development". 

The aim of care for patients suffering from brain injury or neurological disease is to provide appropriate patient specific therapeutic interventions based on reliable diagnostic and monitoring data. Key monitoring components involve intracranial pressure (ICP), cerebral perfusion pressure (CPP) and cerebrovascular autoregulation (CVA). ICP is a fundamental neurophysiological parameter because of its importance in intracraniospinal dynamics, its direct effect on cerebral perfusion, and its correlation with prognosis and outcome in head-injury patients.

Importance of ICP is the same as of arterial blood pressure (ABP) because cerebral blood flow is influenced by CPP, with CPP = ABP- ICP. Importantly, cerebral blood flow depends on the status of cerebrovascular autoregulation. Individual optimal CPP (optCPP) means patient- specific CPP at which CVA is kept intact by individual treatment actions in order to decrease the rate of unfavorable patients’ treatment outcome. Currently, only invasive ICP monitoring technologies are available within the contemporary brain injury management. The ambitious technological task of developing non-invasive ICP and CVA monitoring technologies suitable for the clinical practice in terms of accuracy and precision as well as identification of the individual optCPP for daily routine is of extreme scientific importance.

The innovative non-invasive ICP and CVA monitoring methods developed in Kaunas University of Technology (KTU) are protected by the US, EU and Japan patents. In this project the prospective clinical studies in Switzerland and Lithuania with traumatic brain injury (TBI) and neurological patients will be conducted in order  1) to assess accuracy and precision of the novel and innovative noninvasive ICP, CVA and optCPP technologies and 2) to develop innovative technological hardware and software solutions in KTU to ensure sufficient accuracy, precision and reliability of proposed technologies in the clinical environment. New fundamental scientific knowledge and innovative patentable technological solutions will be produced during this project. The developed productive knowledge and intellectual property will be used for the development of Worlds first non-invasive ICP meter and first fast non-invasive optCPP identifier suitable for clinical practice. 

Project partners:

Kaunas University of Technology (Coordinator) website

Kantonsspital Aarau Neurochirurgische Klinik

Lithuanian University of Health Sciences 

 

For more information on the Lithuania Swiss programme, please visit the Research Council of Lithuania website and Swiss Agency for Development and Cooperation (SDC) website.

 

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