Intraocular pressure vs intracranial pressure in disease conditions: A prospective cohort study (Beijing iCOP study)

Authors: Li Z, Yang Y, Lu Y, Liu D, Xu E, Jia J, Yang D, Zhang X, Yang H, Wang N, Ma D.

BACKGROUND: Whether intraocular pressure (IOP) can be used as a non-invasive surrogate of intracranial pressure (ICP) remains unknown. The aim of the current study was to determine whether there was a correlation between ICP and IOP.
METHODS: The IOP measured with Goldmann applanation tonometer was carried out on 130 patients whose ICP was determined via lumber puncture. The Pearson correlation coefficient between ICP and IOP was calculated , the fisher line discriminated analysis to evaluate the effectivity of using IOP to predict the ICP level.
RESULTS: A significant correlation between ICP and IOP was found. ICP was correlated significantly with IOP of the right eyes (P 0.001) and IOP of the left eyes (P = 0.001) and mean IOP of both eyes (p 0.001), respectively. However, using IOP as a measurement to predict ICP, the accuracy rate was found to be 65.4%.
CONCLUSION: Our data suggested that although a significant correlation exists between ICP and IOP, caution needs to be taken when using IOP readings by Goldmann applanation tonometer as a surrogate for direct cerebrospinal fluid pressure measurement of ICP.

Full text and source: BMC Neurology

BMC Neurol. 2012 Aug 3;12(1):66.