Genetics of Alzheimer Disease
Authors: Rao AT, Degnan AJ, Levy LM.
SUMMARY:Alzheimer disease prevails as a major cause of disability in the elderly population and ranks as the most common form of dementia that affects 1 of 8 individuals older than 65 years of age. Most AD cases are late in onset and are probably influenced by both genetic and environmental factors. Apart from age, the risk factors include family history; brain injury, both traumatic and vascular; and metabolic diseases, such as diabetes, hypercholesterolemia, and obesity. Based on twin studies, inheritance plays a role in approximately 80% of cases (familial and sporadic).
Full text and source: American journal of neuroradiology
AJNR Am J Neuroradiol. 2013 Mar 28.